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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
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Digital Screening for Cognitive Impairment - A Proof of Concept Study
V Bloniecki1, G Hagman, M Ryden
1Victor Bloniecki, Karolinska Institute, Karolinska Uinversity Hospital, Eugeniavägen 3, SE-17176, Stockholm, Sweden. Tel.: +46 70-726 82 20;
The Journal of Prevention of Alzheimer'S Disease
|February 11, 2021
Summary
The Geras Solutions Cognitive Test (GCST) shows promise as an accurate and efficient tool for early detection of cognitive impairment and dementia. It demonstrates comparable sensitivity and specificity to the MoCA test.
Area of Science:
- Neurology
- Gerontology
- Cognitive Science
Background:
- An aging global population is experiencing a rise in cognitive impairment and dementia.
- The development of disease-modifying treatments necessitates early and accurate diagnostic tools.
- Existing cognitive screening instruments require enhancement for early detection of neurodegenerative disorders.
Purpose of the Study:
- To evaluate the validity and accuracy of the novel digital Geras Solutions Cognitive Test (GCST).
- To compare the performance of GCST against the established Montreal Cognitive Assessment (MoCA).
Main Methods:
- 106 patients with memory complaints were recruited from a memory clinic.
- Participants underwent assessment for neurodegenerative disorders and received both MoCA and GCST.
- Statistical analyses included descriptive statistics, sensitivity, specificity, and ROC curves.
Main Results:
- Both GCST and MoCA showed significant differences in mean scores across diagnostic subgroups (SCI, MCI, dementia).
- GCST exhibited higher sensitivity (0.91) and comparable specificity (0.55) versus MoCA (0.88 sensitivity, 0.54 specificity).
- GCST demonstrated significantly shorter total test times across diagnostic groups.
Conclusions:
- The Geras Solutions Cognitive Test (GCST) is a viable digital instrument for cognitive screening.
- GCST shows potential for the early detection of Mild Cognitive Impairment (MCI) and dementia.
