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Microbial-derived antigens and metabolites in spondyloarthritis

Katharine Lu Yang1, Alannah Lejeune1, Gregory Chang2

  • 1Department of Pathology, NYU School of Medicine, 522 First Ave. Smilow Research Bldg 511, New York, NY, 10016, USA.

Seminars in Immunopathology
|February 11, 2021
PubMed

Insights

Spondyloarthritis (SpA) involves gut dysbiosis and altered microbial metabolites. Research highlights how these changes in intestinal microbiota influence SpA development and pathogenesis.

Area of Science:

  • Immunology
  • Microbiology
  • Gastroenterology

Background:

  • Spondyloarthritis (SpA) encompasses chronic, immune-mediated inflammatory conditions affecting joints and connective tissues.
  • The gut microbiome, a complex community of microorganisms, significantly impacts host health and disease processes.
  • Gut dysbiosis, an imbalance in the gut microbiome, is increasingly linked to the pathogenesis of SpA.

Purpose of the Study:

  • To review novel findings on the role of microbial metabolites and antigens in Spondyloarthritis.
  • To provide an overview of how gut microbiota alterations contribute to SpA pathogenesis.

Main Methods:

  • Review of recent human and animal studies.
  • Analysis of research on microbial metabolites and antigens in SpA.

Main Results:

  • Gut dysbiosis in SpA is characterized by altered microbial metabolites.
  • Changes in intestinal microbiota composition and function can modulate SpA pathogenesis.
  • Specific microbial metabolites and antigens are implicated in SpA development.

Conclusions:

  • Microbial metabolites and antigens play a crucial role in the pathogenesis of Spondyloarthritis.
  • Understanding the gut microbiome's contribution offers potential therapeutic targets for SpA.
Keywords:
Ankylosing spondylitisMCFAMetaboliteMicrobial metaboliteMicrobial triggerMicrobiotaPolyaminePsoriatic arthritisSCFAShort chain fatty acidSpASpondyloarthritisTh17TrimethylamineTryptophan

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