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Tau in the gut, does it really matter?

Pascal Derkinderen1,2, Malvyne Rolli-Derkinderen1, Guillaume Chapelet1,3

  • 1Inserm, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Université de Nantes, Nantes, France.

Journal of Neurochemistry
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Summary
This summary is machine-generated.

The enteric nervous system, or

Keywords:
Crohn's diseaseTaualpha-synucleinenteric nervous systemgastrointestinal tractgut-brain axisisoforms

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Neurodegenerative Diseases

Background:

  • The enteric nervous system (ENS) functions as the 'second brain' due to its structural and functional similarities with the central nervous system (CNS).
  • Neurodegenerative diseases affecting the CNS, such as Parkinson's disease with alpha-synuclein pathology, can also impact the ENS.
  • The role of tau protein in the ENS, analogous to its role in brain disorders, is an emerging area of research.

Purpose of the Study:

  • To review current literature on tau expression and phosphorylation in the ENS.
  • To explore the presence and significance of tau in the ENS under physiological and pathological conditions.
  • To discuss the potential for 'enteric tauopathies' as a distinct disease entity.

Main Methods:

  • Literature review of studies investigating tau in the enteric nervous system.
  • Analysis of tau expression and phosphorylation patterns.
  • Comparison of ENS tau pathology with CNS tauopathies.

Main Results:

  • Alpha-synuclein pathology is common in the ENS of Parkinson's disease patients.
  • Research on tau in the ENS is nascent, with limited studies available.
  • The potential for tau pathology in the ENS requires further investigation.

Conclusions:

  • The homology between CNS and ENS suggests shared disease mechanisms.
  • Tau protein may play a role in ENS dysfunction and neurodegeneration.
  • Further research is needed to understand and define 'enteric tauopathies'.