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[Isoniazid-inducedtoxic hepatitis].

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Isoniazid treatment for latent tuberculosis infection (LTBI) can cause severe liver injury. This case highlights the importance of monitoring liver function to prevent serious complications.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Isoniazid is a primary treatment for latent tuberculosis infection (LTBI).
  • Hepatotoxicity is a known, potentially severe side effect of isoniazid therapy.
  • Early detection and management are crucial for preventing progression to liver failure.

Observation:

  • A 39-year-old male developed acute hepatitis during standard isoniazid treatment for LTBI.
  • The patient experienced severe liver injury, necessitating consideration of liver transplantation.
  • Despite the severity, the patient achieved full hepatic regeneration without transplantation.

Findings:

  • This case illustrates a severe, yet reversible, instance of isoniazid-induced acute hepatitis.
  • The patient's recovery underscores the liver's regenerative capacity.
  • The incident occurred despite standard treatment protocols for LTBI.

Implications:

  • Routine biochemical monitoring during LTBI treatment is essential for early detection of hepatotoxicity.
  • Implementing vigilant follow-up can prevent severe isoniazid-related liver complications.
  • This case emphasizes the need for proactive patient management in LTBI treatment programs.