A mitochondria-targeted dual-functional aggregation-induced emission luminogen for intracellular mitochondrial
Yujie Zhang1, Wendi Huang1, Xueying Tan2
1Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China. hujiaabo@zju.edu.cn and Institute of Drug Discovery Technology, Ningbo University, Ningbo, 315000, Zhejiang, China. wangjinhui@nbu.edu.cn.
Biomaterials Science
|February 11, 2021
Abstract:
A mitochondria-targeted dual-functional aggregation-induced emission luminogen, TPP-TPEDCH, was rationally designed and developed for intracellular mitochondrial imaging and photodynamic therapy. TPP-TPEDCH clearly showed the movements of mitochondria at various time points. Moreover, both in vitro and in vivo results demonstrated its excellent ROS generation ability and strong antitumor activity.
