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A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
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Metal homeostasis in pathogenic Epsilonproteobacteria: mechanisms of acquisition, efflux, and regulation

Brittni R Kelley1, Jacky Lu2, Kathryn P Haley3

  • 1Department of Microbiology, University of Tennessee, Knoxville, TN, USA.

Metallomics : Integrated Biometal Science
|February 11, 2021
PubMed

Insights

Pathogenic bacteria like Campylobacter jejuni and Helicobacter pylori face metal challenges in hosts. They adapt gene expression and virulence to manage metal scarcity or toxicity during infection.

Area of Science:

  • Microbiology
  • Pathogen-host interactions
  • Bacterial physiology

Background:

  • Epsilonproteobacteria, including Campylobacter jejuni and Helicobacter pylori, are significant human pathogens.
  • These bacteria colonize the gastrointestinal tract, leading to various diseases.
  • Host immune responses involve metal sequestration or toxic metal accumulation to combat pathogens.

Purpose of the Study:

  • To review the challenges of metal availability for C. jejuni and H. pylori at the host-pathogen interface.
  • To describe the adaptive mechanisms these bacteria employ in response to metal fluctuations.

Main Methods:

  • Literature review of current research on Epsilonproteobacteria.
  • Analysis of host-pathogen interactions concerning metal metabolism.
  • Examination of bacterial gene expression and virulence factor deployment.

Main Results:

  • Host strategies impact metal availability for C. jejuni and H. pylori.
  • These pathogens possess sophisticated systems to sense and respond to metal limitation or overload.
  • Bacterial adaptation involves altering gene expression and virulence factor production.

Conclusions:

  • Metal availability is a critical factor at the host-pathogen interface for Epsilonproteobacteria.
  • C. jejuni and H. pylori exhibit remarkable physiological adaptability to survive metal stress.
  • Understanding these adaptations is key to developing novel therapeutic strategies.
Keywords:
CampylobacterHelicobacterEpsilonproteobacteriametalpathogen

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