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Updated: Nov 17, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Pyrimidin-6-yl Trifluoroborate Salts as Versatile Templates for Heterocycle Synthesis
David L Cousins1, Prisca Fricero1, Kenji P M Kopf1
1Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
Abstract:
We report a novel and general method to access a highly under-studied privileged scaffold-pyrimidines bearing a trifluoroborate at C4, and highlight the broad utility of these intermediates in a rich array of downstream functionalization reactions. This chemistry is underpinned by the unique features of the trifluoroborate group; its robustness provides an opportunity to carry out chemoselective reactions at other positions on the pyrimidine while providing a pathway for elaboration at the C-B bond when suitably activated.
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