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Endosalpingiosis Is Negative for GATA3
Marissa J White1, Russell Vang1, Pedram Argani1
1From the Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, Maryland.
Archives of Pathology & Laboratory Medicine
|February 11, 2021
Summary
GATA3 immunohistochemistry can help distinguish endosalpingiosis from metastatic breast cancer. GATA3 is typically negative in endosalpingiosis, aiding accurate diagnosis in challenging cases.
Area of Science:
- Pathology
- Oncology
- Immunohistochemistry
Background:
- Endosalpingiosis can mimic metastatic low-grade breast cancer in lymph nodes.
- Immunohistochemistry is crucial for differentiating these conditions.
- GATA3 is a known breast carcinoma marker, but its role in endosalpingiosis diagnosis was unevaluated.
Purpose of the Study:
- To determine if GATA3 immunohistochemistry can differentiate endosalpingiosis from metastatic mammary carcinoma.
Main Methods:
- 15 cases of endosalpingiosis were analyzed using GATA3 immunohistochemistry.
- Nuclear GATA3 labeling was assessed for percentage and intensity.
- Cases included lymph nodes and pelvic tissues.
Main Results:
- GATA3 immunohistochemistry was negative in all endosalpingiosis cases.
- Focal, weak GATA3 labeling was observed in benign fallopian tube epithelium.
- Lymphocytes served as positive controls, showing intact labeling.
Conclusions:
- GATA3 immunohistochemistry is a valuable tool for diagnosing endosalpingiosis.
- It can be incorporated into immunopanels to differentiate from metastatic breast cancer.
- GATA3 negativity supports endosalpingiosis, while positivity suggests mammary carcinoma.
