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Successful management of idiopathic intestinal pseudo-obstruction with cisapride
N P Cohen1, I W Booth, K Parashar
1Children's Hospital, Birmingham, United Kingdom.
Insights
A case report details an 11-year-old boy with chronic intestinal pseudo-obstruction. Intravenous cisapride led to remission, maintained by rectal administration, highlighting its efficacy.
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Motility Disorders
Background:
- Chronic intestinal pseudo-obstruction (CIPO) is a rare motility disorder.
- CIPO can present in children, significantly impacting quality of life.
Abstract:
This is a case report of a previously asymptomatic 11-year-old boy who developed chronic intestinal pseudo-obstruction. Barium studies revealed grossly disordered motility of the proximal small bowel, and ganglion cells in a gastric biopsy were mildly abnormal. Treatment with conventional prokinetic agents and gastrojejunostomy were ineffective. Intravenous cisapride induced an immediate remission, which has been maintained subsequently by rectal administration of the drug.