Responses to exercise training in patients with heart failure. Analysis by oxygen transport steps

Exercise training (ET) increases exercise tolerance, improves quality of life and likely the prognosis in heart failure patients with reduced ejection fraction (HFrEF). However, some patients do not improve, whereas exercise training response is still poorly understood. Measurement of cardiac output during cardiopulmonary exercise test might allow ET response assessment according to the different steps of oxygen transport.

Fifty-three patients with HFrEF (24 with ischemic cardiomyopathy (ICM) and 29 with dilated cardiomyopathy (DCM) had an aerobic ET. Before and after ET program, peak oxygen consumption (VO_2peak) and cardiac output using thoracic impedancemetry were measured. Oxygen convection (QO_2peak) and diffusion (DO₂) were calculated using Fick's principle and Fick's simplified law. Patients were considered as responders if the gain was superior to 10%.

We found 55% VO_2peak responders, 62% QO_2peak responders and 56% DO₂ responders. Four patients did not have any response. None baseline predictive factor for VO_2peak response was found. QO_2peak response was related to exercise stroke volume (r = 0.84), cardiac power (r = 0.83) and systemic vascular resistance (SVR_peak) (r = -0.42) responses. Cardiac power response was higher in patients with ICM than in those with DCM (p < 0.05). Predictors of QO2_peak response were low baseline exercise stroke volume and ICM etiology. Predictors of DO₂ response were higher baseline blood creatinine and prolonged training.

The analysis of the response to training in patients with HFrEF according to the different steps of oxygen transport revealed different phenotypes on VO_2peak responses, namely responses in either oxygen convection and/or diffusion.