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Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
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Adrenergic signalling in osteoarthritis.

Rebecca Sohn1, Gundula Rösch1, Marius Junker1

  • 1Dr. Rolf M. Schwiete Research Unit for Osteoarthritis, Department of Orthopedics (Friedrichsheim), University Hospital Frankfurt, Goethe University, Frankfurt / Main, Germany.

Cellular Signalling
|February 11, 2021
PubMed
Summary
This summary is machine-generated.

Adrenergic receptors (ARs) in the joint, activated by norepinephrine, contribute to osteoarthritis (OA) pathogenesis. Targeting these ARs offers potential for OA prevention and treatment.

Keywords:
AdrenoceptorsNorepinephrineOsteoarthritisSympathetic nervous system

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Area of Science:

  • Neuroscience
  • Orthopedics
  • Pharmacology

Background:

  • Adrenoceptors (ARs) mediate sympathetic neurotransmitter effects, crucial in cardiovascular medicine.
  • Osteoarthritis (OA) involves joint tissue degradation, inflammation, and pain, with growing interest in sympathetic nervous system involvement.
  • Sympathetic nerve fibers release norepinephrine (NE) in the joint, and joint tissues express various AR subtypes.

Purpose of the Study:

  • To review background knowledge on ARs and their signaling pathways.
  • To summarize recent findings on NE-induced AR signaling in OA joint tissues.
  • To explore the potential of targeting adrenergic signaling for OA prevention or treatment.

Main Methods:

  • Literature search of the PubMed database.
  • Keywords included 'joint', 'cartilage', 'synovium', 'bone', 'osteoarthritis', 'trauma', 'sympathetic nerve fibers', 'norepinephrine', 'adrenergic receptors', and 'adrenergic therapy'.
  • Narrative review focusing on ARs, NE signaling in OA, and therapeutic potential.

Main Results:

  • ARs are present in various joint tissues and are activated by NE.
  • NE signaling through ARs plays a role in OA pathogenesis.
  • Targeting ARs presents a potential therapeutic strategy for OA.

Conclusions:

  • Adrenergic signaling is implicated in osteoarthritis pathogenesis.
  • Targeting adrenoceptors may offer novel therapeutic strategies for osteoarthritis.
  • Further research into adrenergic signaling in OA is warranted.