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Updated: Nov 17, 2025

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
[Prenatal Radiation Exposure in Nuclear Medicine]
Christian Happel1, Markus Borowski2, Alexandra Kamp3
1Universitätsklinikum Frankfurt am Main; Klinik für Nuklearmedizin.
New guidelines from the German Society of Medical Physics offer improved methods for calculating radiation exposure to unborn children during nuclear medicine procedures. These updates ensure better risk assessment for pregnant patients undergoing medical imaging.
Area of Science:
- Medical Physics
- Radiology
- Nuclear Medicine
Background:
- Radiation exposure during pregnancy from nuclear medicine raises patient and professional concerns.
- Previous guidelines for prenatal radiation exposure calculations were outdated.
- Advances in nuclear medicine imaging and radiotracers necessitated a revision.
Purpose of the Study:
- To review the 2019 revised German report on prenatal radiation exposure.
- To highlight changes relevant to nuclear medicine, including a new dose calculation concept.
- To provide guidance for estimating radiation exposure to the unborn.
Main Methods:
- Review of the 2019 "Prenatal Radiation Exposure Arising from Medical Indication, Dose Calculation, Conclusions for Physicians and Pregnant Women" report.
- Comparison of the revised 2-step dose calculation concept with the previous 3-step approach.
- Analysis of adaptations for new devices, hybrid imaging, and radiotracers.
Main Results:
- A revised 2-step dose calculation concept replaces the former 3-step method.
- Step 1 uses diagnostic reference levels (DRLs) for conservative estimation; if below 20 mSv, no further action is needed.
- Step 2 involves dose calculation based on administered activity and gestational stage for higher exposures or therapies.
Conclusions:
- The revised DGMP report provides essential guidance for estimating prenatal radiation exposure.
- The new calculation concept is more adaptable to modern nuclear medicine practices.
- Updated guidelines ensure better-informed decisions regarding radiation use in pregnant patients.
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