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Updated: Nov 17, 2025
12:13
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
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Post-Translational Modifications That Drive Prostate Cancer Progression.
1Laboratory for Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Biomolecules
|February 12, 2021
Summary
Post-translational modifications (PTMs) dynamically regulate protein function and are crucial in driving prostate cancer. Understanding PTMs offers new therapeutic strategies for prostate cancer treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Protein function is modulated by post-translational modifications (PTMs) beyond genetic code.
- PTMs are vital for cellular responses, gene regulation, protein localization, and proteostasis.
- PTMs play a significant role in the development and progression of prostate cancer.
Purpose of the Study:
- To explore post-translational modifications with a significant role in driving prostate cancer.
- To present a comprehensive overview of proteome-wide and single protein PTMs in prostate cancer.
- To detail the enzymes involved in PTMs and their impact on phenotypic outcomes.
Main Methods:
- Collected and reviewed data on specific PTMs (phosphorylation, glycosylation, ubiquitination, SUMOylation, acetylation, lipidation) in prostate cancer.
- Identified enzymes responsible for these PTMs.
- Compiled information on the involvement of PTMs in prostate cancer phenotypes.
Main Results:
- Detailed the involvement of phosphorylation, glycosylation, ubiquitination, SUMOylation, acetylation, and lipidation in prostate cancer.
- Highlighted the critical role of PTMs when protein expression or mutation status is unchanged.
- Demonstrated that differential protein activity can be regulated by PTMs.
Conclusions:
- Post-translational modifications are key drivers of prostate cancer.
- Understanding PTMs is crucial for advancing prostate cancer treatment strategies.
- Current therapeutic approaches targeting PTMs in prostate cancer are presented.
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