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Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography

Efstratios Karagiannidis1, Andreas S Papazoglou1, Nikolaos Stalikas1

  • 1First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636 Thessaloniki, Greece.

Journal of Personalized Medicine
|February 12, 2021
PubMed

Insights

Serum ceramides may help identify patients with ST-elevation myocardial infarction (STEMI) who have a higher thrombus burden. Higher ceramide levels correlate with larger thrombus volumes and worse blood flow, aiding in risk stratification.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Imaging

Background:

  • ST-elevation myocardial infarction (STEMI) is a major global cause of mortality.
  • Identifying novel biomarkers is crucial for understanding acute coronary syndromes and personalizing treatment.
  • Ceramides, a class of lipids, are implicated in various cardiovascular processes.

Purpose of the Study:

  • To investigate the correlation between serum ceramide levels and thrombus characteristics in STEMI patients.
  • To assess the association of ceramides with aspirated thrombus volume and angiographic outcomes.
  • To determine if ceramides can serve as predictive biomarkers for thrombus burden.

Main Methods:

  • Studied 38 STEMI patients undergoing primary percutaneous coronary intervention and thrombus aspiration.
  • Quantified aspirated thrombus volume using micro-CT.
  • Measured serum ceramide levels (C16:0, C24:0, C24:1).
  • Assessed angiographic outcomes including TIMI thrombus grade and TIMI flow.
  • Performed Spearman correlation and Receiver Operating Characteristic (ROC) analyses.

Main Results:

  • Higher serum levels of ceramides C16:0, C24:0, and C24:1 were significantly associated with larger aspirated thrombus volume and intracoronary thrombus burden (TB).
  • Ceramide C16:0 levels correlated with worse pre- and post-procedural TIMI flow.
  • ROC analysis indicated that ceramides C24:0 and C24:1 could significantly predict higher intracoronary TB.

Conclusions:

  • Serum ceramide levels are elevated in STEMI patients with greater thrombus burden.
  • Quantification of serum ceramides may enhance risk stratification for STEMI patients.
  • Ceramides show potential as biomarkers for personalized treatment strategies in acute coronary syndromes.

Keywords:
ST-elevation myocardial infarctionceramidesmicro-CTthrombusthrombus aspiration

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