Creatine in Health and Disease
Richard B Kreider1, Jeffery R Stout2
1Human Clinical Research Facility, Exercise & Sport Nutrition Lab, Department of Health & Kinesiology, Texas A&M University, College Station, TX 77843, USA.
Nutrients
|February 12, 2021
Summary
Creatine supplementation offers significant health and therapeutic benefits beyond exercise. This review confirms its role in cellular metabolism, injury recovery, and chronic disease management across all life stages.
Area of Science:
- Cellular Metabolism and Bioenergetics
- Nutritional Science
- Gerontology and Rehabilitation Medicine
Background:
- Creatine is crucial for cellular energy, especially under stress.
- Impaired creatine transport/storage can negatively impact metabolism.
- Adequate creatine availability may mitigate disease and injury severity.
Purpose of the Study:
- To systematically review evidence on creatine for aging health.
- To assess creatine supplementation for injury recovery and chronic disease management.
- To conclude on creatine's health and disease benefits.
Main Methods:
- Systematic review of peer-reviewed scientific and medical literature.
- Analysis of studies on creatine's role in general health and aging.
- Evaluation of creatine supplementation for recovery and disease management.
Main Results:
- Creatine plays a vital role in cellular metabolism, particularly during stress.
- Supplementation may enhance cellular metabolism, aiding recovery from injury.
- Evidence supports creatine's role in managing chronic diseases and improving health outcomes.
Conclusions:
- Creatine supplementation demonstrates broad health and therapeutic benefits.
- These benefits extend across the entire lifespan.
- Creatine is a valuable nutritional strategy for health maintenance and disease management.
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