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Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models
Saloni Saxena1, Herman P Spaink1, Gabriel Forn-Cuní1
1Institute of Biology Leiden, Animal Science and Health, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands.
Biology
|February 12, 2021
Summary
Nontuberculous mycobacteria (NTMs) cause serious infections and are increasingly resistant to antibiotics. This review explores NTM drug resistance mechanisms and models for developing new therapies to combat these challenging pathogens.
Area of Science:
- Microbiology
- Infectious Diseases
- Drug Discovery
Background:
- The genus *Mycobacteria* includes *Mycobacterium tuberculosis* (tuberculosis) and *M. leprae* (leprosy).
- Nontuberculous mycobacteria (NTMs) such as *M. avium*, *M. abscessus*, and *M. ulcerans* complexes are causing a global increase in infections.
- NTMs exhibit high resistance to conventional antibiotics, similar to tuberculosis, necessitating new therapeutic strategies.
Purpose of the Study:
- To review the molecular mechanisms of drug resistance in NTM.
- To discuss current models for evaluating new antimicrobial therapies against NTM.
Main Methods:
- Literature review of scientific articles and research papers.
- Analysis of existing data on NTM drug resistance and therapeutic models.
Main Results:
- Identification of key molecular mechanisms contributing to NTM drug resistance.
- Overview of established and emerging models for NTM drug screening and development.
Conclusions:
- Understanding NTM drug resistance mechanisms is crucial for developing effective treatments.
- Current models provide a foundation for discovering and testing novel therapies against NTM infections.
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