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Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene-Implication for Cardiovascular Health

Nurul 'Izzah Ibrahim1, Isa Naina Mohamed1

  • 1Pharmacoepidemiology and Drug Safety Unit, Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia.

Life (Basel, Switzerland)
|February 12, 2021
PubMed

Insights

Squalene (SQ) shows promise as an alternative cardiovascular treatment due to its antioxidant and anti-inflammatory effects. This review explores how SQ

Area of Science:

  • Biochemistry
  • Cardiology
  • Pharmacology

Background:

  • Cardiovascular diseases (CVD) are the leading global cause of mortality.
  • Hyperlipidemia is a primary risk factor for CVD.
  • Statins are the standard treatment but have side effects leading to nonadherence.

Purpose of the Study:

  • To explore the antioxidant and anti-inflammatory effects of Squalene (SQ).
  • To investigate the interdependence of these effects on cardiovascular health.
  • To assess SQ as a potential alternative or supplementary treatment for CVD.

Main Methods:

  • Literature review on Squalene's biochemical properties.
  • Analysis of studies on SQ's antioxidant and anti-inflammatory mechanisms.
  • Examination of research linking these mechanisms to cardiovascular protection.

Main Results:

  • Squalene (SQ) exhibits significant antioxidant activity.
  • SQ demonstrates anti-inflammatory properties.
  • Evidence suggests a link between SQ's antioxidant and anti-inflammatory actions and cardioprotection.

Conclusions:

  • Squalene (SQ) possesses both antioxidant and anti-inflammatory properties relevant to cardiovascular health.
  • The interplay between these effects may offer a novel therapeutic strategy.
  • SQ presents a potential alternative or adjunct therapy for managing cardiovascular diseases.

Keywords:
anti-inflammatoryantioxidantinterdependenceoxidative stresssqualene

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