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Research Progress on the Cardiac Injury from ACE2 Targeting in SARS-CoV-2 Infection

Hao Sun1, Xiaojuan Su1, Lingyi Huang2

  • 1Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Biomolecules
|February 12, 2021
PubMed

Insights

The novel coronavirus (SARS-CoV-2) can cause cardiac injury through mechanisms involving angiotensin-converting enzyme 2 (ACE2). Understanding these pathways aids in detecting symptoms and developing treatments for COVID-19 patients.

Area of Science:

  • Virology
  • Cardiology
  • Pathogenesis

Background:

  • The global COVID-19 pandemic caused by SARS-CoV-2 poses significant health risks.
  • While pulmonary injury is recognized, SARS-CoV-2 also affects the heart, with unclear underlying mechanisms.
  • Developing effective vaccines and antiviral therapies is a global priority.

Purpose of the Study:

  • To review the structural characteristics of SARS-CoV-2 and its interaction with ACE2.
  • To describe cardiac manifestations associated with SARS-CoV-2 infection.
  • To explore the mechanisms of cardiac injury mediated by ACE2 following viral invasion.

Main Methods:

  • Literature review focusing on SARS-CoV-2 structure and ACE2.
  • Analysis of reported cardiac symptoms in COVID-19 patients.
  • Exploration of molecular mechanisms linking viral entry via ACE2 to cardiac damage.

Main Results:

  • SARS-CoV-2 utilizes ACE2 as a receptor for cell entry.
  • Cardiac injury is a documented complication of SARS-CoV-2 infection.
  • ACE2 plays a crucial role in the pathogenesis of SARS-CoV-2-induced cardiac damage.

Conclusions:

  • Understanding the interaction between SARS-CoV-2 and ACE2 is vital for elucidating cardiac injury mechanisms.
  • This knowledge can facilitate earlier detection of cardiac symptoms in COVID-19.
  • Identifying therapeutic targets related to ACE2 may lead to improved patient outcomes.
Keywords:
ACE2COVID-19SARS-CoV-2spike

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