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Published on: January 18, 2017
Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid
Rabia Batool1, Azhar Rasul1, Ghulam Hussain2
1Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Pakistan.
Abstract:
Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.
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