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Updated: Nov 17, 2025
05:51
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
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Gut microbiota composition and arterial stiffness measured by pulse wave velocity: case-control study protocol (MIVAS
Rita Salvado1, Sandra Santos-Minguez2, Cristina Agudo-Conde3
1Primary Health Care Research Unit of Salamanca (APISAL), Health Service of Castilla y León (SACyL), Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Castilla y León, Spain ritasalvado@usal.es.
BMJ Open
|February 12, 2021
Summary
This study investigates the link between gut bacteria and arterial stiffness in adults aged 45-74. Understanding intestinal microbiota composition may offer new insights into cardiovascular disease prevention.
Area of Science:
- Cardiovascular Disease Research
- Microbiome and Health Studies
- Arterial Stiffness Assessment
Background:
- Intestinal microbiota plays a role in cardiovascular disease (CVD) development.
- A balanced gut microbiome (symbiotes) is crucial for health promotion.
- Arterial stiffness is a significant indicator of cardiovascular risk.
Purpose of the Study:
- To analyze the relationship between intestinal microbiota composition and arterial stiffness.
- To explore the role of gut bacteria in the physiopathology of cardiovascular diseases.
Main Methods:
- Observational case-control study involving 500 participants (250 cases, 250 controls) aged 45-74.
- Arterial stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) and Cardio-Ankle Vascular Index (CAVI).
- Gut microbiome composition analyzed via 16S ribosomal RNA sequencing of fecal samples.
Main Results:
- Study aims to describe gut microbiota in patients with arterial stiffness.
- Data will be collected from Spanish (EVA study) and Portuguese (Guimarães/Vizela study) cohorts.
- Lifestyle and body composition factors will also be assessed.
Conclusions:
- Findings will enhance understanding of gut microbiota's role in arterial stiffness.
- Results may inform novel strategies for cardiovascular disease prevention and management.
- This research contributes to the growing evidence linking gut health to vascular function.
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