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Combinations using checkpoint blockade to overcome resistance

Stefania Morganti1,2, Giuseppe Curigliano1,2

  • 1Division of Early Drug Development for Innovative Therapies, European Institute of Oncology (IEO), IRCCS, Via Ripamonti n.435, 20141, Milan, Italy.

Ecancermedicalscience
|February 12, 2021
PubMed

The advent of immunotherapy for cancer represented a paradigm shift in the treatment approach of neoplasia. Immune-checkpoint inhibitors (ICIs) were demonstrated to significantly improve outcomes, including overall survival across several cancer types, with yearly-durable responses. Nevertheless, many patients derive minor or no benefit with immune checkpoint (IC)-blockade, including patients with cancer types traditionally considered immunogenic. Combination strategies of ICIs with chemotherapy, radiotherapy, targeted therapies or other immunotherapy compounds have been conceived in order to boost the immune-responses and potentially overcome resistance to ICIs. This review focuses on mechanisms underlying resistance to IC-blockade and provides an overview of potential advantages and limitations of combination strategies currently under investigation.

Keywords:
NGIMchemo-immunotherapyimmune-checkpoint inhibitorsimmunotherapy combinationsimmunotherapy resistancenext-generation immune modulatorstargeted therapy

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