Memory, Subjective Memory and Motor Functioning in Non-Demented Elders With and Without Parkinson's Disease

Area of Science:

• Neurology
• Cognitive Science
• Gerontology

Background:

• Parkinson's Disease (PD) is a progressive neurological disorder affecting motor and non-motor functions.
• Memory impairments, both objective and subjective, are common in PD, potentially impacting quality of life.
• The influence of depressive symptoms on memory deficits in PD requires further clarification.

Purpose of the Study:

• To investigate the impact of Parkinson's Disease on objective memory (working and semantic) and subjective memory.
• To examine the relationship between working memory, gait, and mobility in individuals with PD.
• To identify predictors of subjective memory issues in Parkinson's Disease.

Main Methods:

• A cohort of 27 early-stage, non-demented Parkinson's Disease patients was matched with 27 healthy controls.
• Participants underwent comprehensive assessments of objective memory, subjective memory, and depressive symptoms.
• Instrumental gait and functional mobility analyses were conducted alongside cognitive testing.

Main Results:

• Parkinson's Disease patients exhibited poorer objective memory performance across all measured domains.
• Individuals with PD showed gait and posture impairments, with working memory selectively linked to these motor functions.
• Parkinson's Disease patients reported lower confidence in their memory compared to healthy controls.

Conclusions:

• Parkinson's Disease significantly affects both objective and subjective memory, independent of depressive symptoms.
• Working memory deficits in PD are associated with motor impairments, highlighting a potential link between cognitive and motor function.
• Understanding these memory changes is crucial for managing Parkinson's Disease progression and patient well-being.