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Updated: Nov 17, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Epigenetic Regulation and Nonepigenetic Mechanisms of Ferroptosis Drive Emerging Nanotherapeutics in Tumor
Yue Cheng1, Yao Xie2, Yan Chen3
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Abstract:
Currently, traditional cancer therapy still falls far short of expectations. However, a variety of invasive cancers that are resistant to chemotherapy (such as platinum drugs, one of the most applied antineoplastics in clinic) and targeted agents are susceptible to ferroptosis. Ferroptosis is a form of cell death that is driven by cell metabolism and iron-dependent lipid peroxidation. Ferroptosis inducers can eliminate the drug resistance of tumor cells in the mesenchymal state, effectively inhibit the drug resistance of acquired tumor cells, and optimize cancer efficacy. Research based on the epigenetic mechanism of ferroptosis is still in the stage of screening and verifying the regulatory effect, and there is no complete regulatory mechanism network. In this review, we expound on the epigenetic regulation and nonepigenetic mechanisms of ferroptosis and review the epigenetic-based mechanisms of tumor therapy potential and emerging nonepigenetic-based therapies (nanotherapeutics).
Insights
Ferroptosis, a metabolic cell death, shows promise against drug-resistant cancers. This review explores its epigenetic and non-epigenetic mechanisms for novel cancer therapies.
Area of Science:
- Biochemistry
- Oncology
- Molecular Biology
Background:
- Traditional cancer therapies often fail, especially against invasive and drug-resistant cancers.
- Ferroptosis, an iron-dependent cell death, offers a potential alternative for treating chemotherapy-resistant tumors.
- Understanding ferroptosis mechanisms is crucial for developing effective cancer treatments.
Purpose of the Study:
- To review the epigenetic and non-epigenetic mechanisms regulating ferroptosis.
- To explore the therapeutic potential of ferroptosis in cancer treatment.
- To discuss emerging nanotherapeutic approaches for ferroptosis induction.
Main Methods:
- Literature review of epigenetic and non-epigenetic regulation of ferroptosis.
- Analysis of ferroptosis inducers and their effects on drug-resistant cancer cells.
- Examination of nanotherapeutics for targeted ferroptosis induction.
Main Results:
- Ferroptosis is effective against various drug-resistant cancers, including those resistant to platinum drugs.
- Epigenetic regulation of ferroptosis is complex and not fully elucidated.
- Nanotherapeutics show potential for enhancing ferroptosis-based cancer therapy.
Conclusions:
- Ferroptosis presents a promising strategy for overcoming cancer drug resistance.
- Further research into epigenetic regulation is needed to fully harness ferroptosis for therapy.
- Emerging nanotechnologies offer new avenues for ferroptosis-targeted cancer treatment.
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