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Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
169
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

180
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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Updated: Nov 17, 2025

Implantation of the Syncardia Total Artificial Heart
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Transseptal chordal replacement: early experience.

Jason H Rogers1, Steven F Bolling2

  • 1Division of Cardiovascular Medicine, University of California, Davis Medical Center, Sacramento, CA, USA.

Annals of Cardiothoracic Surgery
|February 12, 2021
PubMed
Summary

Transcatheter mitral valve chordal replacement offers a less invasive approach to treating primary mitral regurgitation. This technique allows real-time adjustments on a beating heart, improving patient outcomes.

Keywords:
Mitral regurgitationchordal replacementtranscathetertransseptal

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Area of Science:

  • Cardiovascular Surgery
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Primary mitral regurgitation often requires chordal replacement for native valve preservation.
  • Current surgical chordal replacement is challenging, demanding significant skill on a non-beating heart.
  • Minimally invasive approaches are needed for safer and earlier treatment.

Purpose of the Study:

  • To review emerging transcatheter transseptal technologies for mitral valve chordal replacement.
  • To discuss device design, efficacy, durability, and clinical trial considerations.
  • To highlight advancements in treating primary mitral regurgitation.

Main Methods:

  • Review of current transcatheter transseptal technologies in development.
  • Discussion of echocardiographic guidance for real-time adjustments.
  • Analysis of device design and clinical trial strategies.

Main Results:

  • Transcatheter methods enable real-time chordal length and position adjustment.
  • These approaches offer potential for safer, earlier intervention.
  • Echocardiographic guidance enhances procedural precision.

Conclusions:

  • Transcatheter transseptal chordal replacement is a promising advancement.
  • Further research is needed on device efficacy, durability, and trial design.
  • This technology could revolutionize mitral regurgitation treatment.