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Updated: Nov 17, 2025

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
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The Mitochondrial Chaperone TRAP1 as a Candidate Target of Oncotherapy

Shulan Xie1, Xuanwei Wang2, Shuyuan Gan1

  • 1Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Oncology
|February 12, 2021
PubMed

Insights

Tumor necrosis factor receptor-associated protein 1 (TRAP1) promotes cancer progression by altering cell metabolism and inhibiting apoptosis. Targeting TRAP1 offers a promising therapeutic strategy for cancer treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a heat shock protein 90 (Hsp90) family member.
  • TRAP1 plays a crucial role in cellular protection against oxidative stress and maintaining mitochondrial integrity.
  • Aberrant TRAP1 expression is linked to various aspects of tumorigenesis.

Purpose of the Study:

  • To review the molecular mechanisms of TRAP1 in regulating tumor progression.
  • To examine TRAP1's role in apoptosis.
  • To summarize advances in developing targeted TRAP1 and Hsp90 inhibitors for cancer therapy.

Main Methods:

  • Literature review of studies on TRAP1 function in cancer.
  • Analysis of TRAP1's involvement in metabolic reprogramming (Warburg phenotype).
  • Investigation of TRAP1's dual role in mitochondrial apoptosis regulation.

Main Results:

  • Mitochondrial TRAP1 drives metabolic reprogramming towards the Warburg phenotype in tumor cells.
  • TRAP1 exhibits anti-apoptotic effects, promoting tumor cell survival.
  • TRAP1 influences cell cycle, motility, invasion, and metastasis.

Conclusions:

  • TRAP1 is a significant therapeutic target in oncology.
  • TRAP1 inhibitors combined with chemotherapy represent a potential new cancer treatment strategy.
  • Targeted inhibition of TRAP1 and Hsp90 shows promise for cancer therapy.
Keywords:
apoptosis resistancecancer therapyinhibitorsmetabolic reprogrammingtumor necrosis factor receptor-associated protein 1tumorigenesis

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