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Updated: Nov 17, 2025
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Iris extramedullary hematopoiesis in choroidal melanoma
Beatrice Gallo1,2, Rana'a T Al-Jamal3, Caroline Thaung4
1Ocular Oncology Service, Moorfields Eye Hospital, Helsinki, Finland.
Purpose:
Extramedullary hematopoiesis (EMH) usually occurs in patients with loss of bone marrow hematopoietic function, and in a vast majority of cases, it involves the liver, the spleen, or the lymph nodes. We report EMH in the iris of patients enucleated for choroidal melanoma (CM).
Methods:
We report a series of three patients with CM, two treated with primary enucleation and one with secondary enucleation.
Results:
Histopathology revealed EMH in the iris of all patients.
Conclusion:
EMH of the iris can be associated with CM in the absence of any hematological or systemic disorders. To the best of our knowledge, our work is the first report of this abnormal histopathological finding.
