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Updated: Nov 17, 2025

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Synthesis of multi-substituted pyridines from ylidenemalononitriles and their emission properties
Juliana M de Souza1, Irini Abdiaj2, Jiaqi Chen3
1Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284-3068, USA. tylermcquade@gmail.com and Departamento de Química, Universidade Federal de São Carlos, São Carlos, SP, 13565-905, Brazil. kleber.oliveira@ufscar.br.
Abstract:
Numerous methodologies to obtain pyridines from ylidenemalononitriles are described in the literature. Nevertheless, they are limited to the use of microwave or conventional heat and few lead to 2,3,4 or 2,3,4,5-substituted pyridines as multi-proposal molecular scaffolds or even universal pyridines. Herein, we present a mild and facile solvent-free methodology to obtain a scope of multi-substituted pyridines at room temperature. We also report an example where one of the resulting amino-nicotinonitriles exhibits a preliminary evidence of aggregation-induced emission (AIE).
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