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Gender-related differences in the risk factors for repeat stone surgery.
Viacheslav Iremashvili1, S Li2, S L Dresner2
1Department of Urology, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Medical Foundation Centennial Building, 1685 Highland Avenue, Madison, WI, 53705, USA. iremashvili@hotmail.com.
Urolithiasis
|February 12, 2021
Summary
Gender influences kidney stone recurrence risk factors. Hypertension, diabetes, Caucasian race, and younger age (<60) predict repeat stone surgery in females but not males, highlighting sex-specific prevention needs.
Area of Science:
- Nephrology
- Urology
- Public Health
Background:
- Nephrolithiasis (kidney stones) recurrence necessitates repeat surgical interventions.
- Understanding risk factors for repeat stone surgery is crucial for effective patient management and prevention strategies.
Purpose of the Study:
- To compare associations between potential risk factors and repeat kidney stone surgery in male and female patients.
- To identify sex-specific predictors of surgical recurrence after nephrolithiasis treatment.
Main Methods:
- Retrospective analysis of 1970 patients undergoing stone surgery (2009-2017) with ≥12 months follow-up.
- Uni- and multivariate Cox regression models were used to analyze risk factors for surgical recurrence stratified by gender.
- Exploration of interactions between gender and patient characteristics on recurrence risk.
Main Results:
- Overall, 21.0% of patients experienced surgical recurrence over a mean follow-up of 4.3 years.
- Hypertension, diabetes, Caucasian race, and younger age (<60 years) were significantly associated with increased risk of repeat surgery exclusively in females.
- Significant interactions between these factors and gender indicated a greater impact on recurrence risk in females.
Conclusions:
- Significant sex-based differences exist in the predictors of repeat nephrolithiasis surgery.
- These findings may inform tailored prevention strategies for kidney stone recurrence, optimizing care for male and female patients.
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