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Trace Elements in Children with Acute Lymphoblastic Leukemia.

Omid Reza Zekavat1, Mehran Karimi1, Fereshteh Majidi1

  • 1Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Asian Pacific Journal of Cancer Prevention : APJCP
|February 12, 2021
PubMed
Summary
This summary is machine-generated.

Childhood acute lymphocytic leukemia (ALL) chemotherapy significantly decreases essential trace elements like zinc and copper. Monitoring and supplementation are crucial for managing treatment side effects and supporting children

Keywords:
AcuteChemotherapyLymphoblastic leukemiatrace elements

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Area of Science:

  • Pediatric Oncology
  • Clinical Chemistry
  • Nutritional Science

Background:

  • Chemotherapy for acute lymphocytic leukemia (ALL) in children can lead to malnutrition and altered serum trace elements.
  • These alterations represent a significant challenge in managing childhood ALL.
  • Understanding the impact of chemotherapy on trace elements is vital for supportive care.

Purpose of the Study:

  • To investigate the changes in six key trace elements (Zinc, Copper, Manganese, Magnesium, Chromium, and Iron) in children with ALL.
  • To evaluate these changes before and after induction chemotherapy.
  • To consider age, gender, and chemotherapy protocol as potential confounding factors.

Main Methods:

  • Atomic absorption spectrometry was used to assess trace element levels.
  • Thirty-six newly diagnosed children with ALL were included in the study.
  • Trace element concentrations were measured pre- and post-induction chemotherapy.

Main Results:

  • A significant decrease in serum levels of Zinc, Copper, Manganese, Magnesium, and Iron was observed after induction chemotherapy.
  • Chromium levels showed a significant decrease only in children younger than 10 and those receiving standard-risk chemotherapy.
  • These findings were adjusted for confounding factors like age, gender, and chemotherapy protocol.

Conclusions:

  • Induction chemotherapy in childhood ALL significantly depletes multiple essential trace elements.
  • The results underscore the importance of complementary and supplementary nutritional management.
  • Further research with larger cohorts and longer follow-up is needed to assess long-term effects on health and quality of life.