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Related Experiment Videos

Typhoid fever in pregnancy.

M Seoud1, G Saade, M Uwaydah

  • 1Department of Obstetrics and Gynecology, American University of Beirut Medical School and Medical Center, Lebanon.

Obstetrics and Gynecology
|May 1, 1988
PubMed
Summary
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This study on typhoid fever in pregnancy found that early treatment with antibiotics like chloramphenicol, ampicillin, or amoxicillin led to satisfactory outcomes for both mother and neonate, with no adverse effects on neonatal health.

Area of Science:

  • Infectious Diseases
  • Maternal-Fetal Medicine
  • Microbiology

Background:

  • Typhoid fever is a significant public health concern, particularly in developing regions.
  • Pregnancy can alter the presentation and management of infectious diseases.
  • Limited data exists on the specific impact of typhoid fever during pregnancy on maternal and neonatal outcomes.

Purpose of the Study:

  • To describe the clinical presentation and diagnostic findings of typhoid fever complicating pregnancy.
  • To evaluate the effectiveness of different antibiotic treatments for typhoid fever in pregnant patients.
  • To assess the impact of timely typhoid fever treatment on neonatal outcomes.

Main Methods:

  • Retrospective case series of fourteen pregnant patients diagnosed with typhoid fever.

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  • Diagnosis confirmed via blood cultures, Widal titers, stool, urine, and cervical cultures.
  • Treatment regimens included chloramphenicol, ampicillin, or amoxicillin.
  • Neonatal outcomes were assessed based on gestational age at diagnosis and treatment initiation.

    • Main Results:

    • Blood cultures confirmed diagnosis in 13 patients; Widal titer in one.
    • Urine and cervical cultures were largely negative; stool cultures showed low positivity.
    • Clinical presentation aligned with historical reports, notably lacking relative bradycardia.
    • Hypothermic response to antipyretics was common.
    • All antibiotic treatments (chloramphenicol, ampicillin, amoxicillin) resulted in satisfactory maternal response.
    • Early treatment in the second or third trimester did not negatively impact neonatal outcomes.

    Conclusions:

    • Typhoid fever in pregnancy presents similarly to non-pregnant individuals, with variations in diagnostic culture yields.
    • Chloramphenicol, ampicillin, and amoxicillin are effective treatments for pregnant patients with typhoid fever.
    • Prompt diagnosis and treatment of typhoid fever during pregnancy are crucial and do not appear to adversely affect neonatal outcomes.