Related Experiment Video
Updated: Nov 17, 2025
13:12
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
46.0K
Personality and behavioral changes after brain tumor resection: a lesion mapping study
Anne-Laure Lemaitre1,2, Guillaume Herbet1,3,4, Hugues Duffau1,3,4
1Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Acta Neurochirurgica
|February 12, 2021
Summary
Diffuse low-grade glioma (DLGG) surgery has minimal impact on personality. However, pre-existing personality traits can predict postoperative behavioral changes, linked to specific brain damage.
Area of Science:
- Neuroscience
- Neurosurgery
- Psychology
Background:
- Diffuse low-grade gliomas (DLGG) often spare cognitive function.
- Personality changes post-DLGG resection remain understudied.
- Investigating DLGG resection's impact on personality and behavior is crucial.
Purpose of the Study:
- To assess personality and behavioral changes after DLGG resection.
- To identify neural correlates of these behavioral changes.
- To explore the relationship between personality and postoperative behavior.
Main Methods:
- Administered NOEPI-R and TCI-R personality questionnaires to 98 DLGG patients and 47 controls.
- Collected hetero-evaluations of executive behavioral changes.
- Utilized voxel-wise and tract-wise lesion-symptom mapping for neural analysis.
Main Results:
- No significant differences in most personality dimensions between patients and controls.
- Behavioral changes (irritability, hypoactivity, etc.) reported in 40-50% of patients.
- Neuroticism predicted postoperative hypoactivity; specific behaviors linked to cortical/white matter damage.
Conclusions:
- DLGG and resection have minor effects on overall personality.
- Personality traits modulate surgically-induced behavioral changes.
- Specific brain lesions correlate with distinct behavioral abnormalities.
