Melatonin role in skeletal muscle disorders

Area of Science:

• Neuroendocrinology
• Skeletal Muscle Physiology
• Nutritional Science

Background:

• Muscle wasting and decline are linked to oxidative damage, mitochondrial dysfunction, and impaired autophagy.
• These cellular impairments contribute to various skeletal muscle disorders.
• Melatonin's role in mitigating these pathological processes is under investigation.

Purpose of the Study:

• To review the impact of melatonin on skeletal muscle disorders.
• To evaluate the potential of melatonin therapy for muscle diseases.
• To clarify melatonin's utility in managing muscle wasting.

Main Methods:

• Literature review of recent scientific data.
• Analysis of in vitro and in vivo studies on melatonin's effects.
• Examination of melatonin's impact on oxidative stress and cellular pathways in muscle.

Main Results:

• Melatonin exhibits significant antioxidant effects, confirmed by numerous studies.
• It counteracts mitochondrial damage and reduces oxidative stress in muscle fibers.
• Melatonin helps restore muscle function, especially in age-related atrophy and sarcopenia.

Conclusions:

• Melatonin demonstrates potential as a dietary supplement for preventing muscle wasting.
• It is particularly relevant for sarcopenia-associated conditions.
• Further research supports melatonin's therapeutic utility in muscle disorders.