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Related Experiment Video

Updated: Nov 17, 2025

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Septic shock: a microcirculation disease.

Daniel De Backer¹, Francesco Ricottilli¹, Gustavo A Ospina-Tascón²

¹Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Belgium.

Current Opinion in Anaesthesiology

|February 12, 2021

Summary

This summary is machine-generated.

Microvascular dysfunction significantly impacts septic shock, leading to persistent alterations in tissue perfusion despite conventional resuscitation. Understanding these microcirculatory changes is crucial for improving patient outcomes.

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Area of Science:

Critical Care Medicine
Physiology
Pathophysiology

Background:

Sepsis resuscitation traditionally focuses on systemic hemodynamics and peripheral perfusion.
Central microvascular perfusion is frequently impaired in sepsis, persisting even when macro-hemodynamic goals are met.

Purpose of the Study:

To discuss the implications of microvascular dysfunction in the pathophysiology of septic shock.
To highlight the role of endothelial dysfunction in sepsis-induced hypotension and organ dysfunction.

Main Methods:

Review of current understanding of microvascular alterations in septic shock.
Analysis of the relationship between microcirculatory changes, endothelial dysfunction, and organ damage.

Main Results:

Endothelial dysfunction is central to sepsis, causing hypotension, inflammation, and increased permeability.
Microvascular alterations in sepsis are characterized by heterogeneous blood flow, impairing tissue oxygenation and correlating with poor outcomes.
Systemic hemodynamic assessment is insufficient to predict therapeutic response or detect microcirculatory derangements.

Conclusions:

Microcirculation plays a pivotal role in sepsis pathophysiology.
Understanding microvascular dysfunction is essential for effective sepsis management, moving beyond solely focusing on systemic hemodynamic variables.
While microcirculation-targeted therapies are still developing, knowledge of these processes is vital for improving tissue perfusion.