Related Experiment Video

Updated: Nov 17, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

9.8K

Immunotherapies and immunomodulatory approaches in clinical trials - a mini review

Mohd Iqbal Yatoo1, Zeenat Hamid2, Izhar Rather1

  • 1Division of Veterinary Clinical Complex, Faculty of Veterinary Sciences and Animal Husbandry, Shuhama, Alusteng Srinagar, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Jammu and Kashmir, India.

Human Vaccines & Immunotherapeutics
|February 12, 2021
PubMed

Insights

Immunotherapies like convalescent plasma and cell-based treatments offer alternative options for COVID-19. Further research is needed for effective, affordable immunotherapeutics against the SARS-CoV-2 pandemic.

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has had a devastating global impact.
  • Limited availability of vaccines and drugs necessitates alternative treatment strategies.

Purpose of the Study:

  • To review current immunotherapeutic and cell-based approaches for COVID-19 treatment.
  • To highlight the need for developing effective and accessible immunomodulatory agents.

Main Methods:

  • Review of existing literature on immunotherapies for COVID-19.
  • Exploration of cell-based therapies, cytokines, and toll-like receptor (TLR) based strategies.

Main Results:

  • Convalescent plasma, immunoglobulins, and monoclonal/polyclonal antibodies are viable immunotherapeutic options.
  • Cell-based therapies (NK cells, T cells, stem cells) show potential against SARS-CoV-2.
  • Cytokine and TLR-based therapies are also under investigation.

Conclusions:

  • Immunotherapies and cell-based treatments represent crucial alternative strategies in the absence of specific drugs or vaccines.
  • Future research should focus on developing cost-effective, convenient, and potent immunotherapeutics and immunomodulators to combat the COVID-19 pandemic.
Keywords:
SARS-CoV-2covid-19immunomodulatorsimmunotherapies

More Related Videos

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

1.0K
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors06:32

Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors

Published on: August 18, 2023

2.5K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
860
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.2K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
320
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.0K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
624
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
264