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Published on: December 15, 2014
Mammographic density changes following BC treatment.
Ibrahem H Kanbayti1, William I D Rae2, Mark F McEntee3
1Diagnostic Radiography Technology Department, Faculty of Applied Medical Sciences, King Abdul-Aziz University, Saudi Arabia; Medical Image Optimisation and Perception Group (MIOPeG), Faculty of Medicine and Health, The University of Sydney, Australia.
Mammographic density changes after breast cancer treatment vary, influenced by baseline density, age, menopausal status, and BMI. Understanding these factors is key for assessing treatment outcomes and recurrence risk.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Mammographic density (MD) reduction correlates with lower breast cancer (BC) recurrence risk and can indicate treatment success.
- Trends in MD post-BC therapies and influencing factors require further investigation.
Purpose of the Study:
- To analyze MD changes following BC treatment.
- To identify factors associated with observed MD changes.
Main Methods:
- 226 BC patients undergoing treatment were analyzed.
- MD assessed using Laboratory for individualized Radiodensity Assessment (LIBRA) software.
- Statistical tests (Wilcoxon, median independent) used for pre/post-treatment MD comparison and factor analysis.
Main Results:
- Significant MD differences (percent density, dense area, nondense area) observed pre- and post-treatment.
- Younger age at diagnosis, premenopausal status, and obesity were linked to more pronounced MD changes.
- MD reduction occurred in patients with high baseline MD, younger diagnosis age, premenopausal status, and normal BMI.
Conclusions:
- Two distinct MD change patterns emerged: increase and decrease.
- Baseline MD, menopausal status, age at diagnosis, and BMI significantly impacted these changes.
