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Published on: April 13, 2015
Clinical characteristics in patients with coronary slow flow phenomenon: A retrospective study
Qiaojuan Huang1, Fan Zhang2, Siyu Chen1
1Department of Cardiology, the First Affiliated Hospital of Chongqing Medical University.
Insights
Coronary slow flow phenomenon (CSFP) involves delayed blood flow without artery blockage. Higher monocyte count, hemoglobin, creatinine, and globulin levels are identified as key predictors and indicators of CSFP severity.
Area of Science:
- Cardiology
- Vascular Biology
- Clinical Medicine
Background:
- Coronary slow flow phenomenon (CSFP) is characterized by delayed coronary blood flow on angiography despite normal epicardial arteries.
- The underlying etiopathogenic mechanisms of CSFP remain largely undetermined.
- Understanding clinical and laboratory predictors is crucial for elucidating CSFP mechanisms.
Purpose of the Study:
- To investigate the clinical characteristics and laboratory indexes associated with CSFP.
- To identify independent predictors of CSFP.
- To provide a foundation for exploring the potential mechanisms driving CSFP.
Main Methods:
- A case-control study involving 145 patients with CSFP and 145 controls with normal coronary arteries.
- Collection of clinical information and peripheral venous blood samples prior to coronary angiography.
- Statistical analysis using logistic regression and Receiver Operating Characteristic (ROC) curve analysis.
Main Results:
- Univariate analysis revealed 19 clinical and laboratory indexes with significant differences between groups.
- Multivariate analysis identified monocyte count, hemoglobin, serum creatinine, and globulin as independent predictors of CSFP.
- Elevated levels of these four parameters were observed in CSFP patients, correlating positively with disease extent.
Conclusions:
- Monocyte count, hemoglobin, serum creatinine, and globulin levels are significant independent predictors of CSFP.
- These parameters demonstrate diagnostic value for CSFP, as indicated by ROC analysis.
- Further research into these markers may elucidate CSFP pathogenesis.
Abstract:
Coronary slow flow phenomenon (CSFP) is a coronary artery disease in which coronary angiography shows no obvious stenosis, but there is a delay in blood flow perfusion. The etiopathogenic mechanisms of CSFP are still unclear. The aim of the present study was to investigate the role of clinical characteristics in patients with CSFP, and to provide a reference for exploring the potential mechanisms of CSFP. Patients with angiographically normal epicardial arteries were enrolled (145 patients with CSFP and 145 normal controls). Collected clinical information and laboratory indexes, which measured by peripheral venous blood samples before coronary angiography. Logistic regression analysis was performed for statistical analysis. The present study found 19 clinical and laboratory indexes with statistical differences between the two groups in univariate analysis. Multivariate analysis showed that monocyte count, haemoglobin, serum creatinine and globulin were independent predictors of CSFP. Moreover, the monocyte count, haemoglobin, creatinine and globulin levels were significantly higher in the CSFP patients than the controls, with positive associations between these parameters and the extent of CSFP. In addition, ROC analysis showed the diagnostic value of the above indexes for CSFP.
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