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Published on: February 28, 2012
Analgesics and warfarin. A case that brings up questions and cautions
1Department of Pharmacy, School of Allied Health, Medical College of Ohio at Toledo.
Abstract:
This case report describes prolongation of a patient's prothrombin time and partial thromboplastin time possibly due to coadministration of warfarin and an overdose of an acetaminophen-propoxyphene combination analgesic. Patients receive warfarin for many indications, and concomitant use of an analgesic agent is commonly required. These patients should be closely observed if a combination acetaminophen-propoxyphene product is prescribed. Finally, patients receiving warfarin should be warned about the risks of use (and overdose) of unprescribed medications.
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