Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Origami Bioinspired Sensor Array Using Nanocluster-Carbon Dot Hybrids for Multiplexed Smell- and Taste-Mimetic Analysis of Blood Plasma in Cancer Detection.

ACS sensors·2026
Same author

Sniffing Out Lung Cancer: Biomimetic Breath Analysis via a Deep Eutectic Solvent-Driven Colorimetric Sensor Array.

Analytical chemistry·2025
Same author

Array of Manganese-Based Bimetallic Metal-Organic-Framework Nanozymes with Enhanced Oxidase-like Catalytic Activity Can Simultaneously Identify and Measure Antioxidants.

Analytical chemistry·2025
Same author

A rapid colorimetric paper-based sensor strip for point-of-care monitoring of the blood plasma coagulation.

Chemical communications (Cambridge, England)·2025
Same author

Miniaturized Sniffing Device based on an Array of Fluorescent Carbon Quantum Dots and Metallic Nanoclusters Efficiently Identifies Hematologic Malignancy in Adults.

Analytical chemistry·2024
Same author

A paper-based chemical tongue based on the charge transfer complex of ninhydrin with an array of metal-doped carbon dots discriminates natural amino acids and several of their enantiomers.

Lab on a chip·2023

Related Experiment Video

Updated: Nov 17, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

16.0K

An All-in-One Solid State Thin-Layer Potentiometric Sensor and Biosensor Based on Three-Dimensional Origami Paper

Shiva Pesaran1, Elmira Rafatmah1, Bahram Hemmateenejad1

  • 1Chemistry Department, Shiraz University, Shiraz 71454, Iran.

Biosensors
|February 13, 2021
PubMed
Summary

This study introduces an origami-based electrochemical paper analytical device (ePAD) for sensitive ion detection. The low-cost, paper-based sensor offers ultra-sensitive detection of glucose and heavy metal ions using minimal sample volume.

Keywords:
biosensorcarbon paste electrodepaper-based origami sensorpotentiometricthree-dimensional microfluidic

More Related Videos

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
07:53

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Published on: April 1, 2016

7.8K
Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

12.1K

Related Experiment Videos

Last Updated: Nov 17, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

16.0K
Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
07:53

Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices

Published on: April 1, 2016

7.8K
Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

12.1K

Area of Science:

  • Electrochemistry
  • Analytical Chemistry
  • Materials Science

Background:

  • Paper-based analytical devices offer low-cost, portable sensing solutions.
  • Origami engineering enables complex 3D structures for integrated analytical functions.
  • Miniaturization of electrochemical sensors is crucial for point-of-care diagnostics.

Purpose of the Study:

  • To develop a novel origami 3D paper-based potentiometric sensor.
  • To demonstrate the sensor's capability for detecting heavy metal ions (Cu(II), Cd2+), hydrogen peroxide, and glucose.
  • To achieve high sensitivity and selectivity using simple paper folding techniques.

Main Methods:

  • Fabrication of a three-part origami electrochemical paper-based analytical device (ePAD).
  • Integration of a carbon-paste composite working electrode and a pencil-drawn pseudo-reference electrode.
  • Modification of electrodes with benzo15-crown-5 for ion selectivity and MnO2 for H2O2 detection.
  • Immobilization of glucose oxidase for glucose biosensing.

Main Results:

  • The sensor exhibited high sensitivity towards Cu(II) and Cd2+ ions using modified electrodes.
  • Detection of H2O2 was achieved with a MnO2-doped electrode.
  • An ultra-sensitive glucose biosensor was successfully developed by incorporating glucose oxidase.
  • The device requires only 10.0 µL of sample and enables automatic sampling.

Conclusions:

  • The origami ePAD is a versatile platform for sensitive electrochemical and biosensing applications.
  • The device's design allows for low sample consumption and simplified operation.
  • This technology holds potential for developing low-cost, portable diagnostic tools.