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Melioidosis: Overview of seropositivity in Malaysia

S F F Hii1, C C Kee2, N Ahmad1

  • 1Bacteriology Unit, Infectious Disease Research Centre, Institute for Medical Research, 50588 Jalan Pahang, Wilayah Persekutuan Kuala Lumpur, Malaysia.

Tropical Biomedicine
|February 13, 2021
PubMed
Abstract

Insights

Children under 15 years old face a significantly higher risk of melioidosis exposure in Malaysia. This highlights the concern for paediatric melioidosis and indicates key risk factors like age and region.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Microbiology

Background:

  • Melioidosis, caused by Burkholderia pseudomallei, is endemic in Malaysia.
  • Limited prevalence data exists for melioidosis in Malaysia, particularly concerning specific demographics.

Purpose of the Study:

  • To investigate the prevalence and risk factors of melioidosis in Malaysia.
  • To identify demographic and geographic factors associated with Burkholderia pseudomallei exposure.

Main Methods:

  • A cross-sectional study analyzing sera suspected for melioidosis from 2013-2014.
  • Data was grouped by age, with a specific focus on children under 15 years old.

Main Results:

  • Children under 15 years old showed a significantly higher exposure risk to Burkholderia pseudomallei (AOR=4.71).
  • Higher seropositivity rates were observed in eastern coastal states and Sarawak.
  • Sabah natives and non-Malaysians exhibited increased risk of exposure.

Conclusions:

  • Age and geographic region are independent risk factors for Burkholderia pseudomallei exposure.
  • Paediatric melioidosis is a significant concern and serves as an indicator of exposure intensity.

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