Interleukin-10 -1082A>G polymorphism and susceptibility to pulmonary Tuberculosis in Lur population of Iran

Tuberculosis (TB) is caused by Mycobacterium tuberculosis is one of the major causes of death. Cytokines play a major role in immune defense against such infectious agents. Polymorphisms in the genes that encodes various cytokines have been associated with tuberculosis susceptibility. In this study we investigated whether IL-10 -1082A>G, -819T>C and -592A>C polymorphisms have any association with the susceptibility to pulmonary TB in the Lur population of Iran. IL-10 polymorphism genotyping was performed by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method in 100 pulmonary TB patients and 100 healthy controls of Lur population. The genotypic frequencies of IL-10 -819T>C and -592A>C polymorphisms did not vary significantly between TB patients and healthy controls. Only, in IL-10 -1082A>G polymorphism, a significantly increased frequency of genotype AG was observed among patients compared with controls (74% in the patients vs. 58% in the controls, P=0.0252, OR=0.485, CI=0.4307-0.5988). The allelic frequencies of IL-10 -1082A>G, -819T>C and -592A>C polymorphisms did not have significant difference between the pulmonary TB patients and the healthy controls. Our results demonstrate that the IL-10 -1082A>G polymorphism may be a valuable marker to predict the risk for the development of TB in the Lur population of Iran.