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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Structural Joints: Cartilaginous Joints01:17

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As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
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Synchondrosis
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Structural Joints: Fibrous Joints01:03

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Elastic Strain Energy for Shearing Stresses01:20

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As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
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Tension Response at Adherens Junctions01:26

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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Stereolithographic 3D printing of extrinsically self-healing composites.

Scientific reports·2019
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A Chitosan Based, Laser Activated Thin Film Surgical Adhesive, 'SurgiLux': Preparation and Demonstration
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Viscoelastically active sutures - A stitch in time?

Louise A France1, Kevin S Fancey1

  • 1Department of Engineering, University of Hull, HU6 7RX, UK.

Materials Science & Engineering. C, Materials for Biological Applications
|February 13, 2021
PubMed
Summary

Polypropylene sutures release stored energy over weeks, promoting wound healing. This viscoelastic energy release enhances cell activity and may accelerate the healing process.

Keywords:
Cell motilityElectric chargeMechanotransductionSuturesViscoelasticityWound healing

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Area of Science:

  • Biomaterials Science
  • Polymer Physics
  • Wound Healing Research

Background:

  • Commercially available polypropylene sutures (Ethicon Prolene) undergo viscoelastic changes after annealing and creep.
  • These changes involve time-dependent energy release and potential electrical charge dissipation.
  • Previous findings suggest reduced hydrophobicity and a possible link to enhanced wound healing.

Purpose of the Study:

  • To directly detect electrical charges released from recovering polypropylene sutures.
  • To investigate the effect of viscoelastically recovering sutures on cell behavior and wound healing.
  • To compare cell responses to recovering, annealed, and as-received suture materials.

Main Methods:

  • Annealing and tensile creep of polypropylene suture filaments.
  • Measurement of time-dependent contraction and recovery force.
  • Direct detection of released electrical charges.
  • Cell culture studies on different suture conditions (recovering, annealed, as-received).

Main Results:

  • Polypropylene sutures release stored viscoelastic energy over weeks, exhibiting contraction and increasing recovery force.
  • Direct detection of electrical charges released during viscoelastic recovery.
  • Significantly increased cell motility and migration towards viscoelastically recovering sutures compared to controls.
  • Evidence suggests enhanced wound healing stimulation by recovering sutures.

Conclusions:

  • Viscoelastic energy release from polypropylene sutures may drive wound healing via mechanotransduction.
  • Released electrical charges potentially enhance this wound healing mechanism.
  • Recovering sutures show a pro-healing effect on cell behavior, suggesting accelerated wound repair.