Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

3.8K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.8K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.2K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.2K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

139
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
139
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

13.0K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.4K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

699
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
699

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes.

Journal of periodontal research·2026
Same author

Nonsteroidal Anti-Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation.

Journal of clinical periodontology·2026
Same author

From the Proteome to Therapeutics: A Multi-Database Approach to Drug Discovery in Periodontitis-An Exploratory Pilot Study.

Journal of clinical periodontology·2026
Same author

Target Trial Emulation to Assess Oral Drug Safety.

Journal of dental research·2026
Same author

Study Design in Clinical and Epidemiologic Research: Observational, Experimental, and Beyond.

Journal of periodontal research·2026
Same author

Target Trial Emulation in Observational Research-Strengths, Limitations, and Methodological Considerations.

Journal of periodontal research·2026

Related Experiment Video

Updated: Nov 17, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.0K

Cannabis use does not impact on type 2 diabetes: A two-sample Mendelian randomization study.

Sebastian-Edgar Baumeister1,2,3, Michael Nolde1,2, Zoheir Alayash1

  • 1Chair of Epidemiology, LMU München, UNIKA-T Augsburg, Augsburg, Germany.

Addiction Biology
|February 13, 2021
PubMed
Summary

This study found no causal link between cannabis use and type 2 diabetes risk. Mendelian randomization analysis confirmed that neither lifetime cannabis use nor cannabis use disorder increases the likelihood of developing diabetes.

Keywords:
cannabisdiabetes

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.1K
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

514

Related Experiment Videos

Last Updated: Nov 17, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.0K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

7.1K
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

514

Area of Science:

  • Genetics
  • Metabolic Disorders
  • Pharmacology

Background:

  • Global increases in cannabis use and type 2 diabetes prevalence necessitate understanding their relationship.
  • Cannabis is known to affect insulin and glucose metabolism, raising questions about its impact on diabetes risk.

Purpose of the Study:

  • To investigate the potential causal effect of lifetime cannabis use and cannabis use disorder on the risk of developing type 2 diabetes.

Main Methods:

  • A Mendelian randomization study utilizing genome-wide association study data.
  • Employed 19 single-nucleotide polymorphisms (SNPs) for lifetime cannabis use and 14 SNPs for cannabis use disorder as instrumental variables.
  • Analyzed data from large cohorts for lifetime cannabis use (N=184,765), cannabis use disorder (2,387 cases/48,985 controls), and type 2 diabetes (74,124 cases/824,006 controls).

Main Results:

  • Mendelian randomization analysis indicated no significant effect of lifetime cannabis use on type 2 diabetes risk (OR=1.00, 95% CI=0.93-1.09, P=0.935).
  • Cannabis use disorder also showed no significant association with an increased risk of type 2 diabetes (OR=1.03, 95% CI=0.99-1.08).
  • Sensitivity analyses confirmed these findings, ruling out substantial pleiotropic effects.

Conclusions:

  • The study provides robust evidence that cannabis use does not causally influence the risk of type 2 diabetes.
  • Findings contribute to the scientific understanding of the metabolic effects of cannabis and its implications for diabetes prevention.