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Apolipoprotein E in hepatocellular liver disease.

C H Florén1

  • 1Department of Medicine, University Hospital, Lund, Sweden.

Scandinavian Journal of Clinical and Laboratory Investigation
|April 1, 1988
PubMed
Summary

Plasma apolipoprotein E levels in patients with liver disease are linked to bile salt concentrations. This association may involve reduced hepatic receptor activity impacting lipoprotein metabolism.

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Area of Science:

  • Biochemistry
  • Hepatology
  • Lipid Metabolism

Background:

  • Apolipoprotein E plays a crucial role in lipoprotein metabolism and transport.
  • Hepatocellular liver disease can significantly alter lipid profiles and protein synthesis.

Purpose of the Study:

  • To investigate apolipoprotein E concentrations in plasma of patients with hepatocellular liver disease.
  • To explore the relationship between apolipoprotein E and plasma bile salt concentrations in this patient group.

Main Methods:

  • Plasma samples were analyzed from 17 patients with hepatocellular liver disease.
  • Apolipoprotein E distribution was determined in plasma density fractions.
  • Correlation analysis was performed between apolipoprotein E, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and bile salt concentrations.

Main Results:

  • Apolipoprotein E was predominantly found in VLDL and LDL fractions (<1.063 kg/l).
  • A significant positive correlation (r=0.63, p<0.01) was observed between VLDL/LDL apolipoprotein E and plasma bile salt concentrations, adjusted for liver protein synthesis.
  • This suggests a potential link between elevated bile salts and altered apolipoprotein E metabolism.

Conclusions:

  • Plasma apolipoprotein E is primarily associated with VLDL and LDL in hepatocellular liver disease.
  • Increased plasma bile salt concentrations correlate with higher levels of apolipoprotein E in VLDL and LDL.
  • This association may be mediated by the down-regulation of hepatic apolipoprotein B, E receptors.

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