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The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
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Antidepressant Drugs: MAOIs and Other Agents01:23

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Related Experiment Video

Updated: Nov 17, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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[Sertraline-induced chronic eosinophilic pneumonia].

P Brancaleone1, O Descamps2, M Piquet1

  • 1Service de pneumologie, centres hospitaliers Jolimont, 7100 La Louvière, Belgique.

Revue Des Maladies Respiratoires
|February 14, 2021
PubMed
Summary

Sertraline, a common antidepressant, can cause chronic eosinophilic pneumonia. This case highlights the importance of considering drug-induced lung disease in patients with respiratory symptoms.

Keywords:
DepressionDrug-induced lung diseaseDépressionInhibiteurs de la recapture de la sérotoninePneumonie à éosinophilesPneumopathie médicamenteusePulmonary eosinophiliaSerotonin reuptake inhibitorsSertraline

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Internal Medicine

Background:

  • Sertraline is a widely prescribed selective serotonin reuptake inhibitor for depression.
  • Interstitial lung disease has been anecdotally linked to sertraline use.

Observation:

  • A 69-year-old patient developed bilateral pneumonitis after 10 months of sertraline treatment.
  • Infectious and autoimmune causes were ruled out; lung biopsy showed eosinophilic lung disease.

Findings:

  • Sertraline was suspected as the cause of chronic eosinophilic pneumonia due to the insidious onset and resolution after drug discontinuation.
  • The patient's respiratory symptoms and imaging findings normalized after stopping sertraline.

Implications:

  • This case underscores the potential for sertraline to induce chronic eosinophilic pneumonia.
  • Clinicians should consider drug-induced lung disease in differential diagnoses for patients presenting with unexplained pulmonary conditions.