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Crosstalk between cyclophilins and T lymphocytes in coronary artery disease

Sandra Gegunde1, Amparo Alfonso1, Rebeca Alvariño1

  • 1Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, 27002, Spain; Grupo Investigación Biosdiscovery, IDIS, Spain.

Experimental Cell Research
|February 14, 2021
PubMed

Insights

Cyclophilins and their receptor CD147 are elevated in patients with coronary artery disease, suggesting a role in inflammation and disease progression. This finding highlights potential therapeutic targets for cardiovascular disease.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Cardiovascular diseases, including coronary artery disease (CAD) and atherosclerosis, are major global health issues.
  • Systemic and local inflammation are increasingly recognized as key contributors to CAD pathogenesis.
  • Cyclophilins and their receptor CD147 are implicated in inflammatory processes, but their specific role in cardiovascular disease remains unclear.

Purpose of the Study:

  • To investigate the physiological relevance of cyclophilins and the CD147 receptor in cardiovascular artery disease.
  • To elucidate the relationship between cyclophilins, inflammation, and CAD.
  • To assess cyclophilin and interleukin levels in patients with varying CAD status.

Main Methods:

  • Serum samples from 30 subjects (10 acute coronary syndrome, 10 chronic CAD, 10 controls) were analyzed.
  • Cyclophilins (A, B, C) and pro-inflammatory interleukins were quantified in serum.
  • Cyclophilin levels and CD147 receptor expression were measured in purified T lymphocytes.

Main Results:

  • Cyclophilin A, B, and C levels were significantly elevated in CAD patients compared to controls.
  • Pro-inflammatory interleukins were significantly higher in patients with CAD.
  • CD147 membrane expression on T lymphocytes was also significantly increased in CAD patients.

Conclusions:

  • Elevated cyclophilins and CD147 expression in CAD patients suggest their involvement in cardiovascular disease pathogenesis.
  • These findings indicate a potential link between cyclophilins, inflammation, and the progression of coronary artery disease.
  • Cyclophilins and CD147 may represent novel therapeutic targets for managing cardiovascular inflammatory conditions.

Keywords:
AtherosclerosisCD147 receptorCoronary artery diseaseCyclophilinsInflammationT lymphocytes

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