Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

171
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
171
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

180
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
180
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

181
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
181
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

146
A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
146
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

169
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
169
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

144
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
144

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of serotonin transporters on myocardial cell injury during ischemia/reperfusion in rats.

The journal of physiological sciences : JPS·2026
Same author

Infectious complications and transplant outcomes in durable left ventricular assist device patients receiving immunosuppressive therapy: case series.

European heart journal. Case reports·2026
Same author

Combined therapeutic strategy of balloon pulmonary angioplasty before and after pulmonary endarterectomy in a patient with severe chronic thromboembolic pulmonary hypertension with Kartagener's syndrome: a case report.

European heart journal. Case reports·2026
Same author

Financial burden of menstrual and menopausal symptoms: productivity loss from absenteeism and presenteeism among working-age women.

Reproductive health·2026
Same author

Treatment strategies for pulmonary arterial hypertension associated with adult congenital heart diseases.

Expert review of clinical pharmacology·2026
Same author

Fenestration Re-creation for Early Fontan Deterioration: Long-Term Hemodynamic and Clinical Outcomes.

Pediatric cardiology·2026

Related Experiment Video

Updated: Nov 17, 2025

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.3K

Reverse left ventricular remodelling after aortic valve replacement for severe aortic insufficiency.

Teppei Toya1,2, Satsuki Fukushima1, Yusuke Shimahara1

  • 1Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.

Interactive Cardiovascular and Thoracic Surgery
|February 14, 2021
PubMed
Summary

Aortic valve replacement (AVR) outcomes for severe aortic insufficiency depend on preoperative left ventricular (LV) function. Preoperative LV ejection fraction (EF) <35% significantly impacts survival and adverse events, with specific biomarkers predicting poor recovery.

Keywords:
Aortic insufficiencyLeft ventricular dysfunctionLeft ventricular mass indexPost-AVR

More Related Videos

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

3.2K
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

28.3K

Related Experiment Videos

Last Updated: Nov 17, 2025

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

5.3K
A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
07:41

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats

Published on: March 1, 2022

3.2K
Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

28.3K

Area of Science:

  • Cardiovascular Surgery
  • Cardiac Imaging
  • Heart Failure Research

Background:

  • Severe aortic insufficiency (AI) poses significant risks to left ventricular (LV) function and overall patient outcomes.
  • Aortic valve replacement (AVR) is a critical intervention, but the long-term impact on LV function recovery requires further investigation.
  • Understanding preoperative LV function is crucial for predicting post-AVR outcomes in AI patients.

Purpose of the Study:

  • To evaluate the long-term results of AVR in patients with severe AI, focusing on LV function.
  • To identify predictive factors influencing LV function recovery and clinical outcomes after AVR for severe AI.
  • To correlate preoperative LV ejection fraction (EF) with survival and major adverse cerebral and cardiovascular events (MACCE).

Main Methods:

  • A cohort of 478 patients undergoing AVR for severe AI was analyzed.
  • Patients were categorized into three groups based on preoperative LV ejection fraction (EF): low (<35%), moderate (35-50%), and normal (>50%).
  • Long-term survival, freedom from MACCE, and LV function recovery (assessed by EF and LV mass index) were evaluated using actuarial methods and multivariable logistic regression.

Main Results:

  • Ten-year survival rates were significantly lower for patients with low preoperative EF (64%) compared to moderate (92%) and normal (93%) EF groups (P=0.016).
  • Ten-year freedom from MACCE was markedly reduced in the low EF group (47%) versus moderate (79%) and normal (84%) EF groups (P<0.0001).
  • Predictive factors for impaired LV function recovery post-AVR in the low EF group included elevated plasma brain natriuretic peptide (>365 pg/mL) and increased LV mass index (>193 g/m2).

Conclusions:

  • Preoperative left ventricular function is a primary determinant of long-term outcomes following AVR for severe aortic insufficiency.
  • Patients with a preoperative EF < 35% face significantly worse survival and higher rates of MACCE.
  • Pre-procedural factors such as EF < 25%, elevated brain natriuretic peptide, and high LV mass index predict a failure to recover ventricular function post-AVR.