Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

292
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
292
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

278
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
278
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

605
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
605
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

8.6K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
8.6K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

498
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
498

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytokine and Antibody Isotype Responses in Vaccinated Healthcare Workers with SARS-CoV-2 Breakthrough Infections.

Viruses·2025
Same author

From Bioinformatic Modeling to Clinical Observation: Potential Implications of Ribosomal RNA Folding in <i>Blastocystis</i> sp. Isolates from Symptomatic and Asymptomatic Carriers.

Pathogens (Basel, Switzerland)·2025
Same author

A clue to clarify the origin of Omicron.

Royal Society open science·2025
Same author

Titers of IgG, IgM, and IgA Against SARS-CoV-2 in Healthcare Workers from a General Hospital in Mexico City.

Diseases (Basel, Switzerland)·2025
Same author

Frequency of Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-10 Gene Polymorphisms in Mexican Patients with Diabetic Retinopathy and Diabetic Kidney Disease.

Pathophysiology : the official journal of the International Society for Pathophysiology·2025
Same author

Association Study of <i>CACNA1D</i>, <i>KCNJ11</i>, <i>KCNQ1</i>, and <i>CACNA1E</i> Single-Nucleotide Polymorphisms with Type 2 Diabetes Mellitus.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Nov 17, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

614

Cervical lymph node tuberculosis and TNF, IL8, IL10, IL12B and IFNG polymorphisms.

Olga Plowes-Hernández1, Héctor Prado-Calleros2, Sara Arroyo-Escalante3

  • 1División de Otorrinolaringología Cirugía de Cabeza y Cuello, Hospital General "Dr. Manuel Gea González", Calzada de Tlalpan 4800, Col. Sección XVI, CP 14080, Ciudad de México, México.

The New Microbiologica
|February 14, 2021
PubMed
Summary

Genetic variations in cytokine genes like TNF, IL8, IL10, and IL12B are associated with cervical lymph node tuberculosis (LNTB) susceptibility in Mexican patients. Further research with larger cohorts is recommended.

Keywords:
Cytokine polymorphismSNPscervical lymph node tuberculosisdisease susceptibilityextrapulmonary TB

More Related Videos

Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.5K
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

10.1K

Related Experiment Videos

Last Updated: Nov 17, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

614
Application of Long-term cultured Interferon-&#947; Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

12.5K
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

10.1K

Area of Science:

  • Immunogenetics
  • Infectious Diseases
  • Tuberculosis Research

Background:

  • Cervical lymph node tuberculosis (LNTB) is the most common form of extrapulmonary tuberculosis.
  • Cytokine gene single nucleotide polymorphisms (SNPs) influence immune responses to tuberculosis (TB).
  • Understanding genetic factors can elucidate LNTB pathogenesis.

Purpose of the Study:

  • To investigate the association between specific cytokine gene polymorphisms (TNF, IL8, IL10, IL12B, IFNG) and LNTB in a Mexican population.
  • To identify genetic markers that may confer susceptibility or protection against LNTB.

Main Methods:

  • Case-control study involving 14 LNTB patients and 138 healthy controls.
  • Genotyping of ten single nucleotide polymorphisms (SNPs) in TNF, IL8, IL10, IL12B, and IFNG genes.
  • Statistical analysis to compare allele and genotype frequencies between groups.

Main Results:

  • Significant associations were found for TNF-238A allele (P=0.03) and TNF-238GA genotype (P=0.03).
  • Significant associations were also observed for IL8+396GG (P=0.01) and IL12B+1188CC (P=0.04) genotypes.
  • Susceptibility haplotypes (TNF-AA, IL10-GTA) and a protective haplotype (IL8-ATT) were identified. No association with IFNG was found.

Conclusions:

  • Specific cytokine gene polymorphisms (TNF, IL8, IL12B) are associated with LNTB in Mexican patients.
  • These findings suggest a role for genetic factors in LNTB manifestation.
  • Larger studies are needed to confirm these associations and explore other cytokine SNPs.