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Cervical lymph node tuberculosis and TNF, IL8, IL10, IL12B and IFNG polymorphisms
Olga Plowes-Hernández1, Héctor Prado-Calleros2, Sara Arroyo-Escalante3
1División de Otorrinolaringología Cirugía de Cabeza y Cuello, Hospital General "Dr. Manuel Gea González", Calzada de Tlalpan 4800, Col. Sección XVI, CP 14080, Ciudad de México, México.
Genetic variations in cytokine genes like TNF, IL8, IL10, and IL12B are associated with cervical lymph node tuberculosis (LNTB) susceptibility in Mexican patients. Further research with larger cohorts is recommended.
Area of Science:
- Immunogenetics
- Infectious Diseases
- Tuberculosis Research
Background:
- Cervical lymph node tuberculosis (LNTB) is the most common form of extrapulmonary tuberculosis.
- Cytokine gene single nucleotide polymorphisms (SNPs) influence immune responses to tuberculosis (TB).
- Understanding genetic factors can elucidate LNTB pathogenesis.
Purpose of the Study:
- To investigate the association between specific cytokine gene polymorphisms (TNF, IL8, IL10, IL12B, IFNG) and LNTB in a Mexican population.
- To identify genetic markers that may confer susceptibility or protection against LNTB.
Main Methods:
- Case-control study involving 14 LNTB patients and 138 healthy controls.
- Genotyping of ten single nucleotide polymorphisms (SNPs) in TNF, IL8, IL10, IL12B, and IFNG genes.
- Statistical analysis to compare allele and genotype frequencies between groups.
Main Results:
- Significant associations were found for TNF-238A allele (P=0.03) and TNF-238GA genotype (P=0.03).
- Significant associations were also observed for IL8+396GG (P=0.01) and IL12B+1188CC (P=0.04) genotypes.
- Susceptibility haplotypes (TNF-AA, IL10-GTA) and a protective haplotype (IL8-ATT) were identified. No association with IFNG was found.
Conclusions:
- Specific cytokine gene polymorphisms (TNF, IL8, IL12B) are associated with LNTB in Mexican patients.
- These findings suggest a role for genetic factors in LNTB manifestation.
- Larger studies are needed to confirm these associations and explore other cytokine SNPs.
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