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Related Experiment Video

Updated: Nov 17, 2025

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
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A Validation Study of the Alcohol Related Neurodevelopmental Disorders Behavioral Checklist.

Marilyn G Klug1, Ann Marie O'Connell2, Amanda Palme2

  • 1Department of Population Health, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.

Alcoholism, Clinical and Experimental Research
|February 14, 2021
PubMed
Summary

The Alcohol Related Neurodevelopmental Disorder Behavioral Checklist (ABC) effectively differentiates children with Fetal Alcohol Spectrum Disorders (FASD) from controls. This validation study confirms its high accuracy as a screening tool for FASD.

Keywords:
AdolescentsChildrenFetal Alcohol Spectrum DisorderScreeningSensitivitySpecificityValidation

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Area of Science:

  • Neurodevelopmental Disorders
  • Pediatric Psychology
  • Diagnostic Tools

Background:

  • The Alcohol Related Neurodevelopmental Disorder Behavioral Checklist (ABC) initially identified 10 measures differentiating children with Fetal Alcohol Spectrum Disorders (FASD) from controls.
  • A prior analysis used 203 children to establish the ABC's factor structure.

Purpose of the Study:

  • To validate the effectiveness of the ABC as a screening tool for FASD in an independent population.
  • To assess the ABC's performance in differentiating children with and without FASD.

Main Methods:

  • A case-control study involved 76 children diagnosed with FASD and 76 matched non-FASD controls.
  • Data from 224 children with existing ABC scores were reviewed.

Main Results:

  • Children with FASD consistently scored higher on all 10 ABC measures compared to non-FASD controls.
  • The ABC demonstrated very high sensitivity and specificity for both the total score and individual measures.

Conclusions:

  • The ABC Screen exhibits robust performance, supporting its use in identifying children with FASD.
  • The tool is effective as an initial step in differentiating FASD from other conditions.