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Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...

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Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Published on: February 22, 2015

Neonatal Central Nervous System Tumors.

Shubin Shahab¹, Jason Fangusaro²

¹Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA; Emory University School of Medicine, 1760 Haygood Drive Northeast HSRB E397, Atlanta, GA 30322, USA.

Clinics in Perinatology

|February 15, 2021

Summary

Neonatal central nervous system (CNS) tumors are rare but serious, presenting unique challenges due to limited treatments and distinct biology. This review covers their presentation, imaging, treatment, prognosis, and psychosocial aspects.

Keywords:

Congenital CNS tumor Congenital brain tumor Fetal CNS tumor Fetal brain tumor Neonatal CNS tumor Neonatal brain tumor

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Area of Science:

Pediatric Oncology
Neuro-oncology
Neonatal Medicine

Background:

Central nervous system (CNS) tumors are the most common pediatric solid tumors.
Neonatal CNS tumors are rare, posing significant challenges due to limited therapeutic options and unique tumor biology.
These tumors often have a poor prognosis in newborns.

Purpose of the Study:

To review neonatal CNS tumors.
To discuss their clinical presentation, imaging characteristics, and treatment strategies.
To explore associated genetic syndromes and the psychosocial impact on families and clinicians.

Main Methods:

Literature review of neonatal CNS tumors.
Analysis of clinical presentation and diagnostic imaging findings.
Synthesis of current treatment approaches and prognostic factors.

Main Results:

Neonatal CNS tumors exhibit distinct clinical and biological features compared to older children.
Diagnostic imaging plays a crucial role in identifying these tumors.
Limited treatment options contribute to the poor prognosis.

Conclusions:

Neonatal CNS tumors require specialized management strategies.
Understanding associated genetic syndromes is vital for comprehensive care.
Addressing the psychosocial needs of affected families and clinicians is essential.